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Abstract #0108

Coronary Wall Thickening in HIV-infected Youth in Association with Antiviral Therapy using Time-Resolved DIR MRI (TRAPD)

Khaled Z. Abd-Elmoniem 1 , Aylin Unsal 1 , Julia B. Purdy 1 , Rohan Hazra 1 , Colleen Hadigan 1 , and Ahmed M. Gharib 1

1 National Institutes of Health, Bethesda, MD, United States

HIV early in life may result in premature vasculopathy and cardiovascular disease. To this effect 35 young adults infected with HIV early in life and 11 health controls were included in this study. All subjects underwent coronary vessel wall imaging using TRAPD method at 3T and coronary MDCT. HIV infected subjects had significantly thicker vessel wall than controls as measured by MR without accompanying difference in plaque burden as measured by CT. The former was related to years of antiviral therapy exposure. This MR method provides evidence of vascular injury in antiviral therapy exposure and not associated with coronary atherosclerosis.

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