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Abstract #0066

Absolute Quantification of Brain Metabolites in Small MRS Voxels

Niklaus Zoelch 1 , Andreas Hock 1,2 , and Anke Henning 1,3

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2 Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland, 3 Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

The goal of this work was to enable absolute quantification of brain metabolites in small voxels, which is desirable in the clinical routine, especially to improve the diagnosis of brain lesion. For this purpose, non-water suppressed MRS via the metabolite cycling technique was combined with the calibration method ERETIC. The combination of these two techniques was tested invivo in 6 healthy volunteers. The concentrations obtained with MC and ERETIC are in good agreement with concentrations determined from water suppressed spectra by using the internal water as reference.

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