Abstract #0066
Absolute Quantification of Brain Metabolites in Small MRS Voxels
Niklaus Zoelch 1 , Andreas Hock 1,2 , and Anke Henning 1,3
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Switzerland,
2
Department
of Psychiatry, Psychotherapy and Psychosomatics,
University of Zurich, Zurich, Switzerland,
3
Max
Planck Institute for Biological Cybernetics, Tuebingen,
Germany
The goal of this work was to enable absolute
quantification of brain metabolites in small voxels,
which is desirable in the clinical routine, especially
to improve the diagnosis of brain lesion. For this
purpose, non-water suppressed MRS via the metabolite
cycling technique was combined with the calibration
method ERETIC. The combination of these two techniques
was tested invivo in 6 healthy volunteers. The
concentrations obtained with MC and ERETIC are in good
agreement with concentrations determined from water
suppressed spectra by using the internal water as
reference.
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