Meeting Banner
Abstract #0065

Caloric Restriction Impedes Age-related Decline of Neuronal Function and Energy Demand

Ai-Ling Lin 1 , Daniel Coman 2 , Lihong Jiang 2 , Douglas L Rothman 2 , and Fahmeed Hyder 2

1 Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Magnetic Resonance Research Center, Yale University, New Haven, CT, United States

While caloric restriction extends mammalian lifespan, its effect on neuronal function and energy demand especially in healthy aging remains largely unknown. Using 1 H[ 13 C] MRS techniques, we show that healthy aging rats had significantly lower rates of neuronal energy production and neurotransmission relative to their younger counterparts; however, caloric restriction mitigated the age-related deceleration of brain physiology. These results provide a rationale for caloric restriction-induced sustenance of brain health with extended lifespan.

This abstract and the presentation materials are available to members only; a login is required.

Join Here