Abstract #0061
Basal ganglia-cortical structural connectivity in Huntingtons disease
Marianne J U Novak 1,2 , Kiran K Seunarine 3 , Clare R Gibbard 2,3 , Bogdan Draganski 4,5 , Karl Friston 1 , Sarah J Tabrizi 2,6 , and Christopher A Clark 3
1
Wellcome Trust Centre for Neuroimaging, UCL
Institute of Neurology, London, United Kingdom,
2
Department
of Neurodegenerative Disease, UCL Institute of
Neurology, London, United Kingdom,
3
Imaging
and Biophysics, UCL Institute of Child Health, London,
United Kingdom,
4
LREN,
Dpartement des Neurosciences Cliniques, Universit de
Lausanne, Switzerland,
5
Max-Planck
Institute for Human Cognitive and Brain Sciences,
Leipzig, Germany,
6
National Hospital for
Neurology and Neurosurgery, London, United Kingdom
Huntington's disease (HD) is a genetic condition that
affects both the white and grey matter of the brain.
Striatal volume loss is the earliest and most
characteristic structural abnormality seen using brain
imaging in HD. In this work we present a statistical
approach that allows us to quantitatively compare
connectivity patterns of subcortical nuclei between
groups. We apply our technique to a Huntington's disease
cohort and find structured differences in patterns of
connectivity compared to healthy controls. Conversely,
we see no significant differences between premanifest HD
patients and controls, which suggests progressive
changes to patterns of connectivity with disease
progression.
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