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Abstract #0060

Diffusion tensor MRI and tractography of the sacral plexus in children with spina bifida

Wieke Haakma 1,2 , Pieter Dik 3 , Bennie ten Haken 4 , Martijn Froeling 1 , Rutger Jan Nievelstein 1 , Jeroen Hendrikse 1 , Inge Cuppen 5 , Tom de Jong 3 , and Alexander Leemans 6

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Department of Forensic Sciences and Comparative Medicine Lab, Aarhus University, Aarhus, Central Denmark, Denmark, 3 Pediatric Urology, University Medical Center Utrecht, Utrecht, Netherlands, 4 Institute for Biomedical Technology & Technical Medicine, University of Twente, enschede, Overijssel, Netherlands, 5 Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands, 6 Image Science Institute, University Medical Center Utrecht, Utrecht, Netherlands

It is still largely unknown how neural tube defects in spina bifida (SB) affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3D could improve anatomical understanding regarding neurological problems. 10 SB patients underwent DTI on a 3 Tesla MRI. With tractography the microstructural properties of the nerves were investigated and were compared with 10 healthy controls. The sacral plexus of SB patients showed asymmetry, disorganization and lower diffusion values compared to healthy controls. We expect that this technology can provide a valuable contribution to a better analysis of these patients in the future.

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