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Abstract #0039

Hybrid PET/MRI incorporating Dynamic 18F-FDG PET Imaging: Correlation with Biopsy Findings-Preliminary Observations

Andrew B Rosenkrantz 1 , Anne-Kristin Vahle 1 , Christian Geppert 2 , Christopher Glielmi 2 , Fabio Ponzo 1 , Kent P Friedman 1 , Samir S Taneja 3 , Yu-Shin Ding 1 , and Thomas Koesters 1

1 Center for Advanced Imaging Innovation and Research, Department of Radiology, NYU Langone Medical Center, New York, NY, United States, 2 Siemens Healthcare, Erlangen, Germany, 3 Urologic Oncology, NYU Langone Medical Center, New York, New York, United States

This pilot study of 12 prostate cancer patients explores associations between metrics obtained from PET/MRI incorporating dynamic 18F-FDG PET imaging and biopsy findings. DCE-MRI and dynamic PET were performed simultaneously following sequential injections of gadolinium-chelate and FDG. Dynamic PET data was reconstructed in 30-second bins for the first 5 minutes, followed by 5-minute bins for the remainder of a 30-minute acquisition. Peak and 30-minute FDG activity were determined from FDG time-activity-curves and compared among benign and low- and high-grade tumors. The peak FDG activity showed the strongest association with biopsy results, supporting the value of dynamic PET imaging during PET/MRI.

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