Meeting Banner
Abstract #0019

Application of multi-shell NODDI in Multiple Sclerosis

Torben Schneider 1 , Wallace Brownlee 1 , Hui Zhang 2 , Olga Ciccarelli 3 , David H Miller 1 , and Claudia A. M. Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, 2 Department of Computer Science & Centre for Medical Image Computing, UCL, London, United Kingdom, 3 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

Neurite orientation and dispersion and density imaging (NODDI) is a new technique that promises unique insight into the density and orientation dispersion of neuronal tissue. In this pilot study we apply NODDI for the first time to Multiple Sclerosis patients and compare with standard DTI metrics. We show that NODDI detects and provides more distinction of the microstructural disruption in Multiple Sclerosis in both lesional tissue and normal appearing white matter compared to healthy controls.

This abstract and the presentation materials are available to members only; a login is required.

Join Here