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Abstract #0018

Accuracy and reliability of ASL perfusion in evaluating neurodegenerative disease: voxel-wise and cortical-regional comparison with 18F-FDG PET

Steve H Fung 1,2 , Christof Karmonik 1,2 , Mario F Dulay 1,2 , Belen Pascual 1,2 , Daniel Y Lee 1,2 , Stephen B Chiang 1,2 , Ronald E Fisher 1,2 , Robert G Grossman 1,2 , Bryan M Spann 1,2 , and Gustavo C Roman 1,2

1 Houston Methodist Research Institute, Houston, Texas, United States, 2 Houston Methodist Hospital, Houston, Texas, United States

Pattern of regional cerebral hypometabolism observed by FDG-PET is well-established technique for diagnosing Alzheimers disease as well as differentiation from other causes of dementia. Recent studies using ASL have shown similar diagnostic utility by observing regional cerebral hypoperfusion pattern. We compared regional and voxel-level CBF estimated from ASL to SUV from FDG-PET, test-retest reliability of CBF from ASL, and CBF from ASL in eyes-open versus eyes-closed states in patients evaluated for neurodegenerative disease. Aside for occipital lobe, we found good correlation between CBF on ASL and SUV on FDG-PET, in agreement with previous published studies. Due to discrepancy in the occipital lobe, caution should be made in interpreting occipital hypoperfusion with ASL, especially when considering dementia with Lewy bodies or Parkinsons disease.

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