Abstract #0011
Longitudinal DTI reveals presymptomatic white matter changes in YAC128 mouse model of Huntington disease
Xin Hong 1 , Ling Guo 1 , Roy Teo 2 , Yi Lin Tay 2 , Xuan Vinh To 1 , Reshmi Rajendran 1 , Si Kang Lew 1 , Yee Ling Tan 1 , Yihui Huang 2 , Michael R. Hayden 2,3 , Mahmoud A. Pouladi 2,3 , and Kai-Hsiang Chuang 1
1
Singapore Bioimaging Consortium, Agency for
Science, Technology and Research, Singapore, Singapore,
Singapore,
2
Translational
Laboratory in Genetic Medicine, Agency for Science,
Technology and Research, Singapore, Singapore,
3
Department
of Medicine, National University of Singapore,
Singapore, Singapore
We performed a longitudinal DTI study to monitor the
microstructural changes in white matter (WM) in
presymptomatic YAC128 mouse model of Huntington's
disease (HD). In YAC128 mice compared to wild-type,
decreased fractional anisotropy and parallel
diffusivity, and increased radial diffusivity are found
in WM regions in a progressive pattern starting from
different ages, as early as 1.5 months. This is preceded
by deficits in myelin-related transcripts as early as 2
weeks of age. Our results suggest that damage to both
myelin and axons may contribute to the observed dynamic
and progressive WM abnormalities in presymptomatic
YAC128 HD model.
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