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Abstract #0011

Longitudinal DTI reveals presymptomatic white matter changes in YAC128 mouse model of Huntington disease

Xin Hong 1 , Ling Guo 1 , Roy Teo 2 , Yi Lin Tay 2 , Xuan Vinh To 1 , Reshmi Rajendran 1 , Si Kang Lew 1 , Yee Ling Tan 1 , Yihui Huang 2 , Michael R. Hayden 2,3 , Mahmoud A. Pouladi 2,3 , and Kai-Hsiang Chuang 1

1 Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore, Singapore, 2 Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore, Singapore, 3 Department of Medicine, National University of Singapore, Singapore, Singapore

We performed a longitudinal DTI study to monitor the microstructural changes in white matter (WM) in presymptomatic YAC128 mouse model of Huntington's disease (HD). In YAC128 mice compared to wild-type, decreased fractional anisotropy and parallel diffusivity, and increased radial diffusivity are found in WM regions in a progressive pattern starting from different ages, as early as 1.5 months. This is preceded by deficits in myelin-related transcripts as early as 2 weeks of age. Our results suggest that damage to both myelin and axons may contribute to the observed dynamic and progressive WM abnormalities in presymptomatic YAC128 HD model.

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