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Abstract #4346

Is Arterial Spin Labeling Effective in Measuring Cerebrovascular Reactivity? A Test-retest Study on Impact of Labeling Efficiency

Taghi Rostami1, Moss Y Zhao2, Audry P Fan3, David Yen-Ting Chen4, Magdalina J Sokolska5, Jia Guo6, Yosuke Ishii7, David D Shin8, Mohamad Mehdi Khalighi2, Dawn Holley2, Kim Halbert2, Andrea Otte2, Brittney Williams2, Jun-Hyung Park2, Bin Shen2, and Greg Zaharchuk2
1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Medical Imaging, UC Davis, Davis, CA, United States, 4Taipei Medical University, Taipei, Taiwan, 5University College London Hospitals, London, United Kingdom, 6University of California Riverside, Riverside, CA, United States, 7Tokyo Medical. and Dental University, Tokyo, Japan, 8GE Healthcare, Menlo Park, CA, United States

In this study, we examined repeatability of labeling efficiency of single- and multi-PLD arterial spin labeling (ASL) MRI before and after vasodilation in 15 normal subjects. Individual measurements of hematocrit and flow velocity in the carotid and vertebral arteries, obtained by phase-contrast (PC) MRI, were used to assess the labeling efficiency for both ASL methods. Our results showed that both labeling techniques achieved high repeatability before and after vasodilation (within-subject Coefficient of Variance pre-ACZ: 0.82 and 1.23%, and post-ACZ: 0.51 % and 1.00%).

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