Diffusion MRI based tractography is widely used to examine structural connectivity in the brain. Due to noises and motions, tractography in individual subject may contain erroneous results, which may be removed by averaging over a group. Although several group average tractography (GAT) approaches are available, their accuracy has not been thoroughly examined. In this study, we compared GAT based on spatial normalization of fiber orientation distribution maps and direct streamline mapping. Our results suggest that direct streamline mapping better preserve small and secondary axonal projections and is better-suited for studying group average tractography of the brain.
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