High Intensity Focused Ultrasound (HIFU) in now entering clinical practice, for example to treat essential tremor (ET) by creating small lesions in the thalamus. Due to small size of treatment lesions, treatment success depends critically on targeting, which is classically done using measurements and landmarks. We explore an alternative method using functional imaging to guide targeting and assess efficacy, specifically using 7T task-related fMRI. We present preliminary data of the patterns of BOLD activation in a set of patients before and after HIFU.
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