Abstract #4230

Can acquisition of pretreatment IVIM parameters in tumor predict the outcomes of osteosarcoma treated by chemotherapy? A preliminary study

Esha Baidya Kayal¹, Devasenathipathy Kandasamy², Kedar Khare³, Raju Sharma², Sameer Bakhshi⁴, and Amit Mehndiratta^1,5

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Radio diagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, ⁵Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

The aim of this study was to investigate the potential of Intravoxel incoherent motion (IVIM) parameters to predict event-free-survival (EFS) in patients with localized osteosarcoma treated by chemotherapy. Quantitative and IVIM parameter estimation and histogram analysis was performed in tumor volume at baseline. Imaging parameters along with clinical features were analyzed to assess their effects on EFS. Results showed, 25^th-percentile of perfusion coefficient (D*) and serum albumin level were significantly associated with EFS among localized osteosarcoma patients.

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