Abstract #4146

Quantification of hemodynamics of cerebral arteriovenous malformations after stereotactic radiosurgery using 4D Flow MRI

Shanmukha Srinivas¹, Tara Retson¹, Aaron Simon², Marc Alley³, Shreyas Vasanawala³, Jona Hattangadi-Gluth², Albert Hsiao¹, and Nikdokht Farid¹

¹Department of Radiology, University of California San Diego, San Diego, CA, United States, ²Department of Radiation Medicine and Applied Sciences, University of California San Diego, San Diego, CA, United States, ³Department of Radiology, Stanford University, Stanford, CA, United States

This study evaluated the use of 4D flow MRI to assess hemodynamic changes to cerebral arteriovenous malformations after stereotactic radiosurgery (SRS). As a comparison, structural changes of AVMs were measured on T₂W single shot fast spin echo (SSFSE) and time-of-flight (TOF) angiography. Hemodynamic changes, including reduction in feeding arterial flow and draining venous flow, preceded structural changes including arterial circumference and nidus volume for large arteriovenous malformations. This study demonstrated the potential utility of 4D flow MRI as a robust tool to supplement existing imaging techniques and measure early treatment response after stereotactic radiosurgery (SRS).

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