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Abstract #4080

A Comparison of Synovitis Severity in the Knee Assessed Using Contrast-Enhanced MRI and FDG-PET

Jacob Thoenen1, James W. MacKay2,3, Kathryn J. Stevens1, Tom D. Turmezei4, Akshay Chaudhari1, Lauren E. Watkins1, Brian A. Hargreaves1, Garry E. Gold1, and Feliks Kogan1
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 4Department of Radiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom

T1-weighted contrast-enhanced MRI (CE-MRI) is used to evaluate synovitis, but fluctuations in severity of synovial inflammation may be slow to manifest as volumetric changes seen on CE-MRI. We compared metabolic activity using FDG-PET to CE-MRI synovitis gradings, MOAKS effusion- and Hoffa-synovitis gradings, and the transfer constant Ktrans in the overall synovial region and four subregions. Moderate to very strong correlation was seen between maximum FDG uptake (SUVmax) and corresponding synovitis grades, MOAKS effusion synovitis, and corresponding regional median Ktrans both within the entire synovium and in four synovial subregions, with the exception of median Ktrans at one subregion.

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