In an MRI-only radiotherapy workflow, in addition to enabling absorbed dose calculation the generated synthetic CT (sCT) must also be valid for patient positioning at treatment course. To evaluate MRI-only patient positioning for head and neck cancer patients, fourteen 3D cone beam CTs were retrospectively registered to CT and sCT. Further, original Digital Reconstructed radiographs originating from the CT and synthetic Digital Reconstructed radiographs originating from the sCT, were retrospectively registered to orthogonal projections. The small mean difference between the registrations showed that sCT could replace the CT for both 3D and 2D head and neck radiotherapy patient positioning.
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