Abstract #4012

Comparison of Diffusion Tractography and fMRI-based Targeting for MRgFUS Treatment of Essential Tremor

Kristin Quah¹, Jonathan Samuel Goodman², Gustavo Loo Kang Chau³, Kim Butts Pauly⁴, Pejman Ghanouni⁴, Gary Glover⁴, and Jennifer McNab⁴

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Biophysics, Stanford University, Stanford, CA, United States, ³Bioengineering, Stanford University, Stanford, CA, United States, ⁴Radiology, Stanford University, Stanford, CA, United States

Probabilistic diffusion tractography and fMRI are two alternative methods for targeting the ventral intermediate nucleus of the thalamus in patients with essential tremor (ET) for treatment with transcranial magnetic resonance imaging-guided focused ultrasound (tcMRgFUS). In this study, three ET subjects underwent MRgFUS thalamotomy with traditional targeting using anatomic landmarks. Tractography and fMRI targeting were compared retrospectively to determine how they relate to one another and to the targets selected by the surgeon. Two of the three subjects showed a consistent spatial relationship between fMRI, tractography and anatomical targets.

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