Abstract #3985

Quantitative susceptibility mapping MRI of brain iron and PET of β-amyloid predict cognitive decline during aging

Lin Chen^1,2, Anja Soldan³, Kenichi Oishi¹, Andreia Faria¹, Marilyn Albert³, Peter van Zijl^1,2, and Xu Li^1,2

¹Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

We investigated associations of brain volume, iron levels as measured by QSM-MRI, and β-amyloid plaque load as measured by ¹¹C-PiB PET imaging on prospective cognitive trajectories, measured using a global and domain-specific cognitive composite scores (e.g., episodic memory, executive function, visuospatial processing and language) in cognitively normal older adults with maximum follow-up of 5 years. Greater volume of multiple cortical and subcortical brain regions was strongly associated with the rate of cognitive decline. Associations between brain iron and β-amyloid and longitudinal cognitive decline were weaker, with brain iron in the basal ganglia and entorhinal cortex predicting global decline.

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