Abstract #3913

Structural and Functional Changes in Patients with Lower Grade Tumors Receiving Partial Brain Radiotherapy: A Longitudinal Study

Alan Finkelstein¹, Arun Venkataraman², Madalina Tivarus³, Md Nasir Uddin⁴, Jianhui Zhong^1,2,3, Giovanni Schifitto^3,4, Michael Milano⁵, Michelle Janelsins⁶, and Sara Hardy^4,5

¹Biomedical Engineering, University of Rochester, Rochester, NY, United States, ²Physics and Astronomy, University of Rochester, Rochester, NY, United States, ³Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁴Neurology, University of Rochester, Rochester, NY, United States, ⁵Radiation Oncology, University of Rochester, Rochester, NY, United States, ⁶Surgery, University of Rochester, Rochester, NY, United States

Patients receiving partial brain radiotherapy (RT) experience cognitive impairment. Determining what structures and networks in the brain are susceptible to RT will help to elucidate mechanisms of cognitive impairment in the setting of RT. In this abstract, we examine structural and functional changes before and 6 months post RT in patients with lower grade brain tumors. Further, graph theory analysis of functional connectivity (FC) data was used to investigate network topology. We found that subcortical volume and local graph theory metrics were significantly correlated with RT dose. We also propose a putative link between volumetric changes and network topology.

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