Effectiveness of split dose of gadoterate meglumine injection using 30% and 70% of standard dose to detect prostate cancer using ultrafast DCE-MRI

We evaluated dynamic contrast enhanced MRI with a split injection protocol for diagnosis of prostate-cancer. We injected 30% of the standard dose, followed after two mins by 70% of the standard dose of gadoterat-meglumine. A signal intensity form of the standard Tofts model was used to extract physiological parameters. On average cancer had larger K^trans and smaller v_e than normal tissue obtained from both doses. Receiver operating characteristic analysis showed that area under curve was 0.776 for a combination of all parameters from the 30% and 70% doses. The split injection protocol combined with quantitative analysis may increase diagnostic accuracy.