Abstract #3868

Spatial Dependence of PDFF Measurement Bias using Chemical Shift Encoded MRI

Nikolaos Panagiotopoulos¹, Thekla Helene Oechtering¹, David Rutkowski², Jean Brittain², Diego Hernando^1,3, and Scott B Reeder^1,3,4

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Calimetrix LLC, Madison, WI, United States, ³Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Departments of Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

A phantom placed alongside a patient, i.e., “pocket phantom,” can enable quality assurance of proton density fat fraction (PDFF) measurements. To determine the optimal positioning, the spatial dependence of PDFF measurements must be understood. To address this unmet need, we filled the bore of a 3T MRI with pocket phantoms. Though PDFF bias was low, it increased with distance from isocenter. Absolute bias was <2.5% within 18cm (in-plane) and within 10cm (z-direction). We conclude that the optimal position for a PDFF pocket phantom is on the table, centered below the patient at the level of the examined organ.

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