We evaluated the robustness of measuring liver and bone marrow PDFF by chemical shift encoded (CSE) MRI measured before and 1-3 days after intravenous (IV) administration of ultra-small superparamagnetic iron oxide (USPIO) particles, i.e., ferumoxytol, as IV contrast. Among the eight included subjects, there was strong linearity and no significant bias between pre- and post-ferumoxytol CSE-MRI liver PDFF (R2=0.99, slope=0.99 and intercept=0.38%; mean bias [limits of agreement]=0.4% [±1.7] at 1.5T, and 0.2% [±1.7] at 3.0T. However, CSE-MRI bone marrow PDFF suffered from bias and overestimation post-ferumoxytol (R2=0.85, slope=0.85, intercept=12.8%, mean bias [LOA]=5.4% [±6.2] at 1.5T and 4.4% [±6.5] at 3.0T).
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