Abstract #3851

Comparing omega-3 content in adipose tissue of mice and rats fed a high omega-3 diet with MRS at 9.4T

Clara J. Fallone¹, Anthony G. Tessier^1,2, Catherine J. Field³, and Atiyah Yahya^1,2

¹Department of Oncology, University of Alberta, Edmonton, AB, Canada, ²Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, ³Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada

Omega-3 (ω-3) fat intake is important to disease and reflected in adipose tissue composition. Optimized PRESS (Point RESolved Spectroscopy) at 9.4T is used to quantify relative ω-3 fat content in adipose tissue of mice and rats fed a 16% ω-3 diet and in a control diet mouse. The actual ω-3 fat content in the mice was determined using gas chromatography and compared to that obtained using optimized MRS (R² = 0.98). On average, the % ω-3 content measured with MRS in rat adipose tissue was approximately 39% higher than that in mouse.

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