In quantitative 129Xe gas exchange MRI, the RBC/barrier ratio is emerging as a robust and important functional metric. However, it depends strongly on how it is measured, specifically on flip angle and repetition time. Moreover, we don’t yet have a clear understanding of its expected range in healthy subjects. Here, we demonstrate that by combining a physical diffusion model of 129Xe signal recovery with the recently introduced concept of flip angle to TR-equivalence, we can estimate the “structural limit” for the maximum RBC/barrier ratio expected in healthy adult subjects at any TR and flip angle.
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