Abstract #3788

Sensitivity and resolution improvement for in-vivo magnetic resonance current density imaging (MRCDI) of the human brain

Cihan Göksu^1,2, Klaus Scheffler^2,3, Fróði Gregersen^1,4,5, Hasan Hüseyin Eroğlu^1,4, Rahel Heule^2,3, Hartwig R. Siebner^1,6,7, Lars G. Hanson^1,4, and Axel Thielscher^1,4

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Amager and Hvidovre, Denmark, ²High-Field Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ⁴Section for Magnetic Resonance, DTU Health Tech, Technical University of Denmark, Kgs Lyngby, Denmark, ⁵Sino-Danish Center for Education and Research, Aarhus, Denmark, ⁶Department of Neurology, Copenhagen University Hospital, Bispebjerg, Denmark, ⁷Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark

Effective use of transcranial electrical stimulation (TES) in clinical and neuroscience applications requires the exact knowledge of TES currents. MRCDI uses MRI to measure the TES-induced magnetic fields for estimating the underlying current flow distributions. Their accuracy highly depends on the sensitivity and spatial resolution of the MR measurements. Here, we propose an advanced gradient-echo-based MRCDI method utilizing an optimized spoiling, acquisition-weighting, and navigators to achieve a noise sensitivity of 84pT at 2×2×3mm³ resolution for a total scan time of less than five minutes. We test the method's performance by phantom and human in-vivo experiments for two TES injection profiles.

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