Abstract #3725

Temporal correlation of functional connectivity and Choline in the monkey brain following ischemic stroke

Chun-Xia Li¹, Frank Tong², Doty Kempf¹, Leonard Howell¹, and Xiaodong Zhang¹

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology, Emory University, Atlanta, GA, United States

Previous studies have suggested cerebral Choline (Cho) is a sensitive marker of acute stroke and could protect the tissue from ischemic injury. Also the relative connectivity (RelCon) could be a robust index to reveal the functional connectivity changes using resting state fMRI (rs-fMRI). The results indicated progressively increased RelCon in secondary somatosensory cortex (RelCon-S2) and a significant positive correlation between RelCon-S2 and relative cerebral Choline level (RelCho) from hyper-acute phase to 96 hours post stroke. The RelCon and RelCho combined detection might be an optimized and promising approach in management and prediction of stroke recovery.

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