Meeting Banner
Abstract #3719

1H-MRS of Primary Progressive and Relapsing-Remitting Multiple Sclerosis in brain white matter compared to healthy controls

Bretta Russell-Schulz1, Jasmyne Kassam2, Michael Waine2, Erin L MacMillan1,3,4, Irene Vavasour1, Helen Cross2, Anthony Traboulsee2, Robert Carruthers2, and Shannon Kolind2,5,6
1Radiology, UBC MRI Research Centre, Vancouver, BC, Canada, 2Medicine, University of British Columbia, Vancouver, BC, Canada, 3Philips Healthcare Canada, Markham, ON, Canada, 4Simon Fraser University's ImageTech Lab, Surrey, BC, Canada, 5Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 6Radiology, University of British Columbia, Vancouver, BC, Canada

This study establishes pre-treatment baseline metabolite concentrations for a longitudinal clinical trial for RRMS and PPMS using 1H-MRS. The high MRS data quality and similar in FWHM across all participants creates a strong baseline for detecting change over time. Furthermore, knowing the pre-treatment concentration and tracking concentration changes in the MS subtypes compared to a baseline HC group will allow us to learn more about the mechanisms of action of this therapy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract