Abstract #3675

Beyond cellularity: Which microstructural features determine the mesoscopic mean diffusivity in meningiomas?

Jan Brabec¹, Filip Szczepankiewicz², Jaromír Šrámek³, Elisabet Englund⁴, Johan Bengzon⁵, Linda Knutsson^1,6, Carl-Fredrik Westin^7,8, Pia C Sundgren^2,9, and Markus Nilsson²

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Diagnostic Radiology, Lund University, Lund, Sweden, ³Institute of Histology and Embryology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁴Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden, ⁵Division of Neurosurgery, Department of Clinical Sciences, Lund University, Lund, Sweden, ⁶Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Harvard Medical School, Boston, MA, United States, ⁸Radiology, Brigham and Women’s Hospital, Boston, MA, United States, ⁹Lund University Bioimaging Center, Lund University, Lund, Sweden

Mean diffusivity (MD) in tumors is often too readily interpreted as cellularity. Here, we investigated which microstructural features explain the MD in meningioma tumors. We performed high-resolution MRI and histological imaging on excised mengioma tumor samples and coregistered MD to histology. We found that cellularity alone was a poor predictor of MD, and that the prediction improved markedly by considering also the microcyst density. A qualitative analysis also indicated that collagen fibers, stroma and psammoma bodies affect the MD.

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