Abstract #3670

Diffusion-time-dependent diffusion MRI based microstructural mapping for grading and categorizing in pediatric brain tumor

ruicheng ba¹, Hongxi Zhang², Zhongwei Gu³, Yuhao Liao¹, Xingwang Yong¹, Zhiyong Zhao¹, Yi Zhang¹, and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hang zhou, Zhejiang, China, ²Children's Hospital, Zhejiang University School of Medicne，Department of Radiology, Hang zhou, Zhejiang, China, ³Children's Hospital, Zhejiang University School of Medicne, Department of Pathology, Hangzhou, Zhejiang, China

Diffusion-time dependent diffusion MRI (dMRI) has been proposed to characterize tumor microstructure. This study aimed to evaluate diagnostic value of time-dependent dMRI based microstructural mapping to grade and categorize pediatric brain tumor at 3T. Oscillating and pulsed gradient dMRI was performed in 35 pediatric patients. Cell diameter (d), intracellular fraction (f_in) and extracellular diffusivity (D_ex) were fitted based on the IMPULSED model. Higher cellularity (f_in/d) and f_in and lower D_ex were found in high-grade glioma than low-grade ones. The cellularity further increased in medulobastoma compared with glioma. Cellularity achieved the highest area-under-the-curve than the other dMRI metrics in grading glioma.

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