Abstract #3625

Increased SNR and improved reproducibility for cardiac 31P MRS at 7T using compartmentalized spectroscopy

Andrew Tyler^1,2, Justin Y C Lau¹, Jane Ellis¹, Jack J Miller^1,2,3, Paul A. Bottomley⁴, Christopher T Rodgers^1,5, Damian J Tyler^1,2, and Ladislav Valkovic^1,6

¹Oxford Centre for Clinical Cardiac Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ²Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ³Department of Physics, University of Oxford, Oxford, United Kingdom, ⁴The Division of MR Research, Johns Hopkins Medicine, Baltimore, MD, United States, ⁵Wolfson Brain Imaging Centre, University of Cambidge, Cambridge, United Kingdom, ⁶Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

The intrinsically low SNR and long acquisition times of ³¹P spectroscopy make translation to clinical practice very challenging, even at ultra-high fields. In this study, 12 healthy volunteers were scanned twice at 7T with a short ³¹P CSI and reduced k-space acquisitions for reconstruction with the SLAM and SLIM algorithms. PCr/ATP ratio and PCr SNR were computed for each scan and coefficients of reproducibility and variability were calculated. Compared to a Fourier based reconstruction of the short ³¹P acquisition, SNR was significantly improved and PCr/ATP was maintained when SLAM and SLIM reconstructions were used.

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