Multidimensional diffusion MRI, specifically, tensor-valued encoding is a promising technique for improving specificity in microstructural measurements in the myocardium beyond that achievable with DTI. Tensor-valued encoding data combining linear and spherical tensor encoding were acquired in ex vivo mouse hearts at 7T, including an isoproterenol-induced model of hypertrophy. Covariance and gamma fitting methods were employed to reconstruct parameter maps reflecting the isotropic and anisotropic components of the diffusion signal kurtosis. The results were consistent across both methods, and highlight the potential of multidimensional diffusion MRI for improving specificity in cardiac diffusion MRI.
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