Cardiac T1-mapping methods often require motion correction. The contrast changes intrinsic to the inversion recovery series often used for this purpose can occasionally cause registration errors, resulting in inaccurate T1 values. It has been shown, using a large database of clinical cases, that accounting for those contrast changes markedly increases the robustness of the correction. A new metric of cardiac anatomy alignment had to be defined, in order to automate the quantitative analysis of the database. This metric was shown to correlate with the visual scoring of misalignment in MOLLI series.
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