Abstract #3608

Altered T1 and T2 relaxation times in leg muscles are linked to hemodynamic and ambulatory parameters in patients with Peripheral Artery Disease.

Constance J Mietus¹, Yue Gao¹, Mariano G Uberti², Nicholas G Lambert¹, Panagiotis Koutakis³, Evlampia Papoutsi³, Jonathan R Thompson¹, Holly K DeSpiegelaere⁴, Michael D Boska², Sara A Myers⁵, George P Casale¹, Iraklis I Pipinos^1,4, and Balasrinivasa R Sajja²

¹Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States, ²Department of Radiology, University of Nebraska Medical Center, Omaha, NE, United States, ³Department of Biology, Baylor University, Waco, TX, United States, ⁴Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE, United States, ⁵Department of Biomechanics, University of Nebraska Omaha, Omaha, NE, United States

Understanding the quantitative MRI features of the myopathy of Peripheral Artery Disease (PAD) may aid in grading disease severity, treatment response, and potentially predicting favorable response to exercise or revascularization surgery. In this study we explored the relationship between T1 and T2 relaxation times and measurements of hemodynamic and ambulatory performance in patients with PAD. T1 relaxation time positively correlated with ankle brachial index and peak plantar flexion and inversely correlated with claudication onset time. T2 relaxation time correlated positively with peak plantar flexion and inversely correlated with ischemic window, claudication onset time, and peak walking time.

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