Abstract #3415

Cumulant expansions for measuring restricted diffusion and water exchange

Arthur Chakwizira¹, Filip Szczepankiewicz², Linda Knutsson^1,3, Pia Sundgren^2,4,5,6, and Markus Nilsson²

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Diagnostic Radiology, Lund University, Lund, Sweden, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁵Department for Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, ⁶Department of Radiology, University of Michigan, Ann Arbor, MI, United States

Cell sizes and membrane permeability can be inferred by probing time–dependent diffusion due to restricted diffusion and water exchange. However, restriction and exchange have opposing effects on the diffusion weighted signal when varying the diffusion time, making it a challenge to disentangle the two phenomena. We explore the applicability of a unified theoretical framework that includes size and exchange in living cells by applying it to healthy and diseased human brain in vivo as well as a yeast phantom. Results highlight the potential of the framework for differentiating between healthy and abnormal tissue.

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