Abstract #3391

Assessing intersubject BOLD synchronization and BOLD-CBF coupling using movie fMRI

Kaden T Shearer¹, Allen A Champagne², Nicole S Coverdale¹, Ingrid S Johnsrude³, and Douglas J Cook⁴

¹Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada, ²Department of Medicine, Queen's University, Kingston, ON, Canada, ³The Brain and Mind Institute, University of Western Ontario, London, ON, Canada, ⁴Department of Surgery, Queen's University, Kingston, ON, Canada

Movie fMRI is a promising alternative to resting state paradigms given its ability to evoke predictable patterns of neuronal activation. However, it remains unknown whether increased reliability of cortical activation is accompanied by increased correlation between the BOLD and CBF signals (BOLD-CBF coupling). This study compared the intersubject synchronization of the BOLD signal across 7 functional brain networks between resting state and movie fMRI, as well as potential differences in BOLD-CBF coupling. Movie fMRI significantly improved the reliability of cortical activation between subjects compared to resting state, although no significant differences in BOLD-CBF coupling were documented.

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