Luminance-dependent laminar activation analysis in human V1 is presented. White and black dot-shaped visual stimuli were used to evoke BOLD responses in the early visual cortex. Traditional on/off block stimulation paradigm and continuous stimulation paradigm without interleaved rest periods were used. With voxel centroid mapping, where each voxel’s relative cortical depth is estimated, activation ROIs across multiple image slices and subjects can be analyzed collectively with minimum smoothing and no resampling of functional data. Results show black-dominant responses in V1, with laminar profiles from continuous stimulation emphasizing the role of middle layers by minimizing the effect of ascending vein drainage.
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