Liver R2* determined with a breath hold GRE sequence is commonly used to address liver iron content in vivo. However, iron occurs in the body bound to various chemical substances. To study influence of chemical composition on R2* on a clinical MRI scanner, we scanned mixtures of two iron compounds, polymer coated nanoparticles on the one hand and diluted Fe3+ ions on the other, at different concentrations of both compounds. We found that the relaxivity of one compound depended on the concentration of the other, suggesting that the interactions between compounds are more complex than previously assumed.
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