A T2-based oximetry pulse sequence has been developed by interleaving a phase-contrast module preceding a background-suppressed T2-prepared echoplanar imaging readout. The method enables rapid simultaneous measurement of blood flow velocity and T2 of blood water protons from a single anatomic location in 18 seconds scan time. The pulse sequence improves on T2-based oximetry methods, including T2-relaxation-under-spin-tagging (TRUST), by incorporating background-suppression to eliminate the need for “control” and “label” images. The pulse sequence also interleaves phase-contrast MRI so that a separate measurement of blood flow velocity is not required to quantify whole-organ metabolic rate of oxygen.
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