Recently, low-field MRI has been shown to improve the sensitivity of oxygen-enhanced (OE) MRI due to the increased relaxivity of oxygen at lower field strengths. In this work, we demonstrate that using self-gated 3D stack-of-spiral OE-MRI we can further improve the sensitivity and repeatability by: 1) using longer free-breathing acquisitions to increase the signal to noise ratio (SNR) of the acquired images, and 2) improving the consistency of respiratory position between two oxygen states. We also demonstrate that these two improvements give us higher temporal SNR which is a measure of sensitivity in quantitative MRI.
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