Abstract #3234

Population Arterial Input Function for Lung Perfusion Imaging

Marta Tibiletti¹, Jo Naish^1,2, John C Waterton^1,3, Paul JC Hughes⁴, James A Eaden⁴, Jim M Wild⁴, and Geoff JM Parker^1,5

¹Bioxydyn Ltd, Manchester, United Kingdom, ²MCMR, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ³Centre for Imaging Sciences,, University of Manchester, Manchester, United Kingdom, ⁴POLARIS, Imaging Sciences, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, ⁵Centre for Medical Image Computing, University College London, London, United Kingdom

In this work, we explore the possibility of extracting a population Arterial Input Function (AIF) to be used in the quantification of lung perfusion using T1-weighted contrast agent-based perfusion imaging. The population AIF averages the shape of first pass of the CA bolus at high temporal resolution in the pulmonary arteries from 90 scans acquired in 50 patients with interstitial lung disease. The population AIF is then scaled by the patient weight. The results of the analysis using a measured AIF and the population AIF are compared.

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