Abstract #3214

Comparison of UTE 1H lung MRI with quantitative CT and hyperpolarized 129Xe diffusion-weighted MRI in IPF

Ho-Fung Chan¹, James A Eaden¹, Nicholas D Weatherley¹, Kevin Johnson², Guilhem J Collier¹, Madhwesha Rao¹, Graham Norquay¹, Jody Bray¹, Smitha Rajaram¹, Andrew J Swift¹, Ronald A Karwoski³, Brian J Bartholmai³, Stephen M Bianchi⁴, and Jim M Wild¹

¹Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ²Radiology and Medical Physics, University of Wisconsin, Madison, WI, United States, ³Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, United States, ⁴Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

A simple signal density-based analysis of UTE ¹H MRI was compared to hyperpolarized ¹²⁹Xe diffusion-weighted (DW)-MRI and CALIPER CT in twelve idiopathic pulmonary fibrosis (IPF) patients at baseline and after 1 year. A statistically significant correlation between the normalized UTE signal and CALIPER interstitial lung disease percentage was observed in the lower lung zone. Trends between UTE signal and ¹²⁹Xe DW-MRI metrics in the lower zone was observed, and no significant longitudinal change in UTE MRI signal was observed. UTE MRI signal is sensitive to IPF lung parenchyma changes and may demonstrate sensitivity to longitudinal changes in a larger cohort.

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