Abstract #3177

IDEAL-CPMG muscle T2-water and Dixon Fat-Fraction Maps in People with Inclusion Body Myositis and Charcot-Marie-Tooth disease Type 1A

Amy R. McDowell¹, Stephen J. Wastling^1,2, Lara Cristiano³, Jasper M. Morrow¹, Matthew R.B. Evans⁴, Christopher D.J. Sinclair¹, Pedro M. Machado¹, Michael Hanna¹, Mary M. Reilly¹, Tarek Yousry¹, and John S. Thornton¹

¹MRC Centre for Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom, ²Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ³Department of Pediatric Neurology and Radiology, Fondazione Policlinico Universitario, Rome, Italy, ⁴St Thomas Hospital, London, United Kingdom

Muscle T₂ and fat-fraction are two promising metrics for sensitive measures of early disease-related changes in muscle for use in clinical trials. However, fat has a longer T₂ than water in muscle and masks underlying increases in water T₂ due to muscle oedema. The IDEAL-CPMG sequence with appropriate image-data processing produces a T₂-water map uncontaminated by the fat signal. This sequence was acquired in healthy volunteers and two different muscular dystrophy disease types. It was found that elevated T₂-water may be a predictor of later progression to fatty-atrophy in muscle, supporting the value of future longitudinal studies to test this.

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