Abstract #3161

Clavulanic Acid Alters Functional Connectivity of the Anterior Cingulate Cortex in Subjects with Cocaine Use Disorder: A Pilot fMRI Study

Helene L Philogene-Khalid^1,2, Eric M Cunningham¹, Mary F Morrison^1,2, and Nicolas R Bolo^3,4

¹Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States, ²Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States, ³Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁴Psychiatry, Harvard Medical School, Boston, MA, United States

Unlike alcohol and nicotine, there is no FDA-approved pharmacological treatment for cocaine use disorder (CoCUD). The purpose of this study was to investigate clavulanic acid (CLAV), a GLT-1 activator, for its potential to treat CoCUD. Resting state fMRI was used to assess changes in the anterior cingulate cortex (ACC) functional connectivity with repeated CLAV for 10 days. CLAV altered the connectivity of ACC with default mode network, motor control, and addiction cue reactivity related regions. This pilot study supports the development of CLAV for CoCUD treatment.

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