Abstract #3034

Simultaneous multi-parameter mapping to characterize Parkinson’s Disease using strategically acquired gradient echo imaging

Yu Shen¹, Xianchang Zhang², Yan Bai¹, Yaping Wu¹, Ewart Mark Haacke³, Bo Wu⁴, Yongsheng Chen⁴, Rui Zhang¹, Rushi Chen¹, Wei Wei¹, and Meiyun Wang¹

¹Department of Medical Imaging, Henan Provincial People’s Hospital & Zhengzhou University, Zhengzhou, China, ²MR Collaboration, Siemens Healthcare Ltd. Beijing China, Beijing, China, ³Wayne State University, Detroit, MI, United States, ⁴Shanghai Zhuyan Medical Technology Company, Shanghai, China

Scanning patients with Parkinson’s disease (PD) is challenging because of tremors. Strategically acquired gradient echo (STAGE) imaging can acquire seven quantitative images relatively quickly. This method could provide comprehensive evaluations of cerebral alterations in PD patients while reducing motion artifacts. This study compared T1, T2*, R2*, and susceptibility-weighted imaging mapping (SWIM) acquired with STAGE imaging between 15 PD patients and 15 healthy controls (HC). Significant differences were found for the T1 and T2* values in several brain areas between PD and HC, suggesting that STAGE imaging is a convenient and powerful tool to investigate PD.

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