The dysfunction of iron metabolism, especially in substantia nigra (SN), in Parkinson’s disease (PD) has been widely acknowledged, but the genetic influence on iron deposition remains largely unknown. Thus, this study aimed to explore the potential genetic impacts on iron deposition in PD patients. Using imaging genetics association analysis, this study discovers two variants, rs602201 and rs198440, have a positive impact on nigral iron deposition in PD. Specifically, patients with rs602201 polymorphism are particularly vulnerable to iron deposition in SN.
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