The purpose of this study was to develop a fully automated reproducible tool for analysis of morphological and compositional quantitative MR parameters in well-defined cartilage sub-fields across the human knee. This tool was deployed to proton and sodium MR images and the reproducibility was assessed by test re-test scan of ten patients at baseline and after eight days. Due to high reproducibility found in this study this tool may be considered as a good alternative to manual evaluation which, as being extremely expertise-dependent and time-consuming, could represents a considerable burden for large clinical osteoarthritis trials.
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