Abstract #2952

Decreased collagen content in tendons of patients with osteoporosis and osteopenia detected with ultrashort echo time cones MRI

Saeed Jerban¹, Yajun Ma¹, Amir Masoud Afsahi¹, Douglas G Chang², Zhao Wei¹, Meghan Shen¹, Mei Wu¹, Alecio Lombardi^1,3, Nicole Le⁴, Jiang Du¹, and Eric Y Chang^1,3

¹Radiology, University of California, San Digeo, La Jolla, CA, United States, ²Orthopaedic Surgery, University of California, San Digeo, La Jolla, CA, United States, ³Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States, ⁴Radiology, VA San Diego Healthcare System, La Jolla, CA, United States

Bone and tendon comprise a highly interactive mechanical unit. Investigating tendons quality during osteoporosis and osteopenia progress is of great interests. Clinical MRI sequences are not often capable of directly visualizing tendon because of the tissue’s short T2. Ultrashort echo time (UTE) MRI combined with magnetization transfer (MT) modeling (UTE-MT) has demonstrated promise as a quantitative technique that is resistant to the magic angle effect. Lower leg tendons in osteopenia and osteoporosis patients were compared with healthy subjects via UTE-MT. Macromolecular fraction (MMF) obtained from UTE-MT modeling showed a significant reduction in osteopenia and osteoporosis patients compared with healthy subjects.

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