Hip osteoarthritis coincides with or is preceded by biochemical changes in articular cartilage,1, 2 which can be measured on a voxel-wise basis with magnetic resonance T1ρ and T2 relaxation times. In this study, we employed principal component analysis to characterize variation in longitudinal changes of hip cartilage T1ρ relaxation times across healthy subjects and those with early-to-moderate hip osteoarthritis. Our results indicated that over two years, a majority of the variation in T1ρ relaxation time changes was located in the deep layers of the acetabular cartilage.
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