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Abstract #2941

Optogenetic fMRI interrogation of the olfactory system

Teng Ma1,2,3, Xunda Wang1,2, Eddie C. Wong1,2, Pit Shan Chong4, Sanchal Sanchayyan4, Lee Wei Lim4, Pek-Lan Khong3, Ed X. Wu1,2, and Alex T. L. Leong1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, 3Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, 4School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

The olfactory system is one of the major sensory systems and has been often linked to numerous non-olfactory regions pivotal for sensory perception and higher-order cognition. However, the extent of where olfactory signals are distributed brain-wide remains poorly described. By optogenetically stimulating the excitatory projection neurons in olfactory bulb (OB), we interrogated the brain-wide functional organization of the olfactory system using fMRI. We revealed that OB neural activity propagated to regions that are associated with higher-order cognition, reward-related behaviors and multisensory processing.

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Abstract