To identify spatiotemporal network alterations at an early stage of AD, we’ve performed rsfMRI and analysed quasi-periodic patterns in 4-month old TgF344-AD rats. We observed spatiotemporal alterations in whole brain network activity, mainly in the basal forebrain and cingulate cortex. Moreover, occurrences of QPPs were significantly lower in TgF344-AD rats. Co-activation of basal forebrain and cingulate cortex, present in wild-type rats, was greatly reduced in TgF344-AD rats. These results highlight the important role of the BFB in orchestrating brain networks and indicate a potential signature to identify early onset changes at the network level.
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